Publications

@article{Titi-Lartey2022-jg,

title = {Toll-like receptor signalling pathways and the pathogenesis of 

 retinal diseases},

author = {Owuraku Titi-Lartey and Imran Mohammed and Winfried M Amoaku},

year  = {2022},

date = {2022-03-01},

journal = {Front. Ophthalmol. (Lausanne)},

volume = {2},

pages = {850394},

publisher = {Frontiers Media SA},

abstract = {There is growing evidence that the pathogenesis of retinal 

 diseases such as diabetic retinopathy (DR) and age-related 

 macular degeneration (AMD) have a significant chronic 

 inflammatory component. A vital part of the inflammatory cascade 

 is through the activation of pattern recognition receptors (PRR) 

 such as toll-like receptors (TLR). Here, we reviewed the past 

 and current literature to ascertain the cumulative knowledge 

 regarding the effect of TLRs on the development and progression 

 of retinal diseases. There is burgeoning research demonstrating 

 the relationship between TLRs and risk of developing retinal 

 diseases, utilising a range of relevant disease models and a few 

 large clinical investigations. The literature confirms that TLRs 

 are involved in the development and progression of retinal 

 diseases such as DR, AMD, and ischaemic retinopathy. Genetic 

 polymorphisms in TLRs appear to contribute to the risk of 

 developing AMD and DR. However, there are some inconsistencies 

 in the published reports which require further elucidation. The 

 evidence regarding TLR associations in retinal dystrophies 

 including retinitis pigmentosa is limited. Based on the current 

 evidence relating to the role of TLRs, combining anti-VEGF 

 therapies with TLR inhibition may provide a longer-lasting 

 treatment in some retinal vascular diseases.},

keywords = {age-related macular degeneration, diabetic retinopathy, genetic   polymorphisms, inflammation, ischaemic retinopathy, retinal   diseases, retinal dystrophies, toll-like receptors},

pubstate = {published},

tppubtype = {article}

}

@article{Tabrizi2021-vu,

title = {Transcription factor control of lymphatic quiescence and 

 maturation of lymphatic neovessels in development and physiology},

author = {Zarah B Tabrizi and Nada S Ahmed and Joseph L Horder and Sarah J Storr and Andrew V Benest},

year  = {2021},

date = {2021-11-01},

journal = {Front. Physiol.},

volume = {12},

pages = {672987},

publisher = {Frontiers Media SA},

abstract = {The lymphatic system is a vascular system comprising modified 

 lymphatic endothelial cells, lymph nodes and other lymphoid 

 organs. The system has diverse, but critical functions in both 

 physiology and pathology, and forms an interface between the 

 blood vascular and immune system. It is increasingly evident 

 that remodelling of the lymphatic system occurs alongside 

 remodelling of the blood microvascular system, which is now 

 considered a hallmark of most pathological conditions as well as 

 being critical for normal development. Much attention has 

 focussed on how the blood endothelium undergoes phenotypic 

 switching in development and disease, resulting in over two 

 decades of research to probe the mechanisms underlying the 

 resulting heterogeneity. The lymphatic system has received less 

 attention, and consequently there are fewer descriptions of 

 functional and molecular heterogeneity, but differential 

 transcription factor activity is likely an important control 

 mechanism. Here we introduce and discuss significant 

 transcription factors of relevance to coordinating cellular 

 responses during lymphatic remodelling as the lymphatic 

 endothelium dynamically changes from quiescence to actively 

 remodelling.},

keywords = {inflammation, lymphangiogenesis, lymphatic, quiescence, transcription factor},

pubstate = {published},

tppubtype = {article}

}

@article{Robinson2020-vc,

title = {Review - Helicobacter, inflammation, immunology and vaccines},

author = {Karen Robinson and Philippe Lehours},

year  = {2020},

date = {2020-09-01},

journal = {Helicobacter},

volume = {25 Suppl 1},

number = {S1},

pages = {e12737},

publisher = {Wiley},

abstract = {Understanding the mechanisms involved in induction and 

 regulation of the immune and inflammatory response to 

 Helicobacter pylori is extremely important in determining 

 disease outcomes. H pylori expresses a plethora of factors that 

 influence the host response. Vaccines against H pylori are 

 desperately needed for the prevention of gastric carcinogenesis, 

 especially with the increasing trends in antimicrobial 

 resistance. This review summarizes some important findings, 

 published between 1 April 2019 and 31 March 2020, in the areas 

 of H pylori-mediated inflammation, immunity and vaccines.},

keywords = {adaptive immunity, cytokines, Helicobacter pylori, inflammation, innate immunity, vaccines},

pubstate = {published},

tppubtype = {article}

}