Publications

@article{Fung2022-uv,

title = {Diabetic retinopathy for the non-ophthalmologist},

author = {Timothy Hm Fung and Bakula Patel and Emma G Wilmot and Winfried Mk Amoaku},

year  = {2022},

date = {2022-03-01},

journal = {Clin. Med.},

volume = {22},

number = {2},

pages = {112\textendash116},

publisher = {Elsevier BV},

abstract = {Diabetic retinopathy is a microangiopathy resulting from the 

 chronic effects of diabetes mellitus. Healthcare professionals 

 often work in isolation to deliver highly specialised care 

 efficiently and effectively for people living with diabetes. It 

 is not uncommon for people with diabetes to be making frequent 

 visits to community and hospital clinics to see a variety of 

 specialists and healthcare professionals, with seemingly little 

 opportunity for coordination of this complex health management 

 programme between the wider team. In a field that is so diverse 

 and rapidly changing, healthcare professionals of all 

 specialties need to be aware of developments across all aspects 

 of diabetes management. In this article, we discuss the 

 epidemiology and natural history of diabetic retinopathy and 

 describe an approach to its assessment and diagnosis. We provide 

 an overview of the principles of diabetic retinopathy management 

 and outline possible future treatments for diabetic retinopathy.},

keywords = {diabetic macular oedema, diabetic retinopathy, intravitreal   injections, laser photocoagulation, vitrectomy},

pubstate = {published},

tppubtype = {article}

}

@article{Titi-Lartey2022-jg,

title = {Toll-like receptor signalling pathways and the pathogenesis of 

 retinal diseases},

author = {Owuraku Titi-Lartey and Imran Mohammed and Winfried M Amoaku},

year  = {2022},

date = {2022-03-01},

journal = {Front. Ophthalmol. (Lausanne)},

volume = {2},

pages = {850394},

publisher = {Frontiers Media SA},

abstract = {There is growing evidence that the pathogenesis of retinal 

 diseases such as diabetic retinopathy (DR) and age-related 

 macular degeneration (AMD) have a significant chronic 

 inflammatory component. A vital part of the inflammatory cascade 

 is through the activation of pattern recognition receptors (PRR) 

 such as toll-like receptors (TLR). Here, we reviewed the past 

 and current literature to ascertain the cumulative knowledge 

 regarding the effect of TLRs on the development and progression 

 of retinal diseases. There is burgeoning research demonstrating 

 the relationship between TLRs and risk of developing retinal 

 diseases, utilising a range of relevant disease models and a few 

 large clinical investigations. The literature confirms that TLRs 

 are involved in the development and progression of retinal 

 diseases such as DR, AMD, and ischaemic retinopathy. Genetic 

 polymorphisms in TLRs appear to contribute to the risk of 

 developing AMD and DR. However, there are some inconsistencies 

 in the published reports which require further elucidation. The 

 evidence regarding TLR associations in retinal dystrophies 

 including retinitis pigmentosa is limited. Based on the current 

 evidence relating to the role of TLRs, combining anti-VEGF 

 therapies with TLR inhibition may provide a longer-lasting 

 treatment in some retinal vascular diseases.},

keywords = {age-related macular degeneration, diabetic retinopathy, genetic   polymorphisms, inflammation, ischaemic retinopathy, retinal   diseases, retinal dystrophies, toll-like receptors},

pubstate = {published},

tppubtype = {article}

}