Publications

@article{Tabrizi2021-vu,

title = {Transcription factor control of lymphatic quiescence and 

 maturation of lymphatic neovessels in development and physiology},

author = {Zarah B Tabrizi and Nada S Ahmed and Joseph L Horder and Sarah J Storr and Andrew V Benest},

year  = {2021},

date = {2021-11-01},

journal = {Front. Physiol.},

volume = {12},

pages = {672987},

publisher = {Frontiers Media SA},

abstract = {The lymphatic system is a vascular system comprising modified 

 lymphatic endothelial cells, lymph nodes and other lymphoid 

 organs. The system has diverse, but critical functions in both 

 physiology and pathology, and forms an interface between the 

 blood vascular and immune system. It is increasingly evident 

 that remodelling of the lymphatic system occurs alongside 

 remodelling of the blood microvascular system, which is now 

 considered a hallmark of most pathological conditions as well as 

 being critical for normal development. Much attention has 

 focussed on how the blood endothelium undergoes phenotypic 

 switching in development and disease, resulting in over two 

 decades of research to probe the mechanisms underlying the 

 resulting heterogeneity. The lymphatic system has received less 

 attention, and consequently there are fewer descriptions of 

 functional and molecular heterogeneity, but differential 

 transcription factor activity is likely an important control 

 mechanism. Here we introduce and discuss significant 

 transcription factors of relevance to coordinating cellular 

 responses during lymphatic remodelling as the lymphatic 

 endothelium dynamically changes from quiescence to actively 

 remodelling.},

keywords = {inflammation, lymphangiogenesis, lymphatic, quiescence, transcription factor},

pubstate = {published},

tppubtype = {article}

}