Publications

@article{Arjuna2024-jn,

title = {Development of samarium-doped phosphate glass microspheres for  internal radiotheranostic applications},

author = {Andi Arjuna and Ben Milborne and Amal Rezka Putra and Theresia Rina Mulyaningsih and Herlan Setiawan and Md Towhidul Islam and Reda Felfel and Ifty Ahmed},

doi = {10.1016/j.ijpharm.2024.123919},

year  = {2024},

date = {2024-03-01},

urldate = {2024-03-01},

journal = {Int. J. Pharm.},

volume = {653},

number = {123919},

pages = {123919},

publisher = {Elsevier BV},

abstract = {Internal radiotherapy delivers radioactive sources inside the 

 body, near to or into malignant tumours, which may be 

 particularly effective when malignancies are not responding to 

 external beam radiotherapy. A pure beta emitter, 90Y, is 

 currently used for internal radiotherapy. However, theranostic 

 radionuclide-doped microspheres can be developed by 

 incorporating 153Sm, which emits therapeutic beta and diagnostic 

 gamma energies. This study investigated the production of high 

 concentrations of samarium-content doped phosphate-based glass 

 microspheres. The glass P60 (i.e. 60P2O5-25CaO-15Na2O) was mixed 

 with Sm2O3 at ratios of 75:25 (G75:Sm25), 50:50 (G50:Sm50) and 

 25:75 (G25:Sm75) and processed via flame spheroidisation. 

 Scanning electron microscopy (SEM) and energy dispersive X-ray 

 (EDX) confirmed the microsphere uniformity with significantly 

 high samarium content up to 44 % in G25:Sm75. Via X-ray 

 diffraction (XRD) analysis, samarium-doped microspheres appeared 

 to be glass-ceramic in nature. Mass-loss, size and pH changes 

 were performed over 28 days, revealing a significant increase in 

 samarium microsphere stability. After 15 min of neutron 

 activation (neutron flux 3.01 $times$ 1013 n.cm-2.s-1), the 

 specific activity of the microspheres (G75:Sm25, G50:Sm50 and 

 G25:Sm75) was 0.28, 0.54 and 0.58 GBq.g-1, respectively. 

 Therefore, the samarium microspheres produced in this study 

 provide great potential for improving internal radiotherapy 

 treatment for liver cancer by avoiding complex procedures and 

 using less microspheres with shorter irradiation time.},

keywords = {flame spheroidisation, Internal radiotherapy, Microspheres, Samarium-doped phosphate glass},

pubstate = {published},

tppubtype = {article}

}

@article{Molinar-Diaz2023-kp,

title = {Optimisation of the flame spheroidisation process for the rapid 

 manufacture of Fe3O4-based porous and dense microspheres},

author = {Jes\'{u}s Molinar-D\'{i}az and John Luke Woodliffe and Elisabeth Steer and Nicola A Morley and Paul D Brown and Ifty Ahmed},

year  = {2023},

date = {2023-03-01},

journal = {Molecules},

volume = {28},

number = {6},

abstract = {The rapid, single-stage, flame-spheroidisation process, as 

 applied to varying Fe3O4:CaCO3 powder combinations, provides for 

 the rapid production of a mixture of dense and porous 

 ferromagnetic microspheres with homogeneous composition, high 

 levels of interconnected porosity and microsphere size control. 

 This study describes the production of dense (35-80 µm) and 

 highly porous (125-180 µm) Ca2Fe2O5 ferromagnetic microspheres. 

 Correlated backscattered electron imaging and mineral liberation 

 analysis investigations provide insight into the microsphere 

 formation mechanisms, as a function of Fe3O4/porogen mass ratios 

 and gas flow settings. Optimised conditions for the processing of 

 highly homogeneous Ca2Fe2O5 porous and dense microspheres are 

 identified. Induction heating studies of the materials produced 

 delivered a controlled temperature increase to 43.7 °C, 

 indicating that these flame-spheroidised Ca2Fe2O5 ferromagnetic 

 microspheres could be highly promising candidates for magnetic 

 induced hyperthermia and other biomedical applications.},

keywords = {calcium ferrites, ceramics, flame spheroidisation, magnetic   hyperthermia, magnetic particles, magnetite, porous microspheres},

pubstate = {published},

tppubtype = {article}

}