Publications

@article{Arjuna2024-jn,

title = {Development of samarium-doped phosphate glass microspheres for  internal radiotheranostic applications},

author = {Andi Arjuna and Ben Milborne and Amal Rezka Putra and Theresia Rina Mulyaningsih and Herlan Setiawan and Md Towhidul Islam and Reda Felfel and Ifty Ahmed},

doi = {10.1016/j.ijpharm.2024.123919},

year  = {2024},

date = {2024-03-01},

urldate = {2024-03-01},

journal = {Int. J. Pharm.},

volume = {653},

number = {123919},

pages = {123919},

publisher = {Elsevier BV},

abstract = {Internal radiotherapy delivers radioactive sources inside the 

 body, near to or into malignant tumours, which may be 

 particularly effective when malignancies are not responding to 

 external beam radiotherapy. A pure beta emitter, 90Y, is 

 currently used for internal radiotherapy. However, theranostic 

 radionuclide-doped microspheres can be developed by 

 incorporating 153Sm, which emits therapeutic beta and diagnostic 

 gamma energies. This study investigated the production of high 

 concentrations of samarium-content doped phosphate-based glass 

 microspheres. The glass P60 (i.e. 60P2O5-25CaO-15Na2O) was mixed 

 with Sm2O3 at ratios of 75:25 (G75:Sm25), 50:50 (G50:Sm50) and 

 25:75 (G25:Sm75) and processed via flame spheroidisation. 

 Scanning electron microscopy (SEM) and energy dispersive X-ray 

 (EDX) confirmed the microsphere uniformity with significantly 

 high samarium content up to 44 % in G25:Sm75. Via X-ray 

 diffraction (XRD) analysis, samarium-doped microspheres appeared 

 to be glass-ceramic in nature. Mass-loss, size and pH changes 

 were performed over 28 days, revealing a significant increase in 

 samarium microsphere stability. After 15 min of neutron 

 activation (neutron flux 3.01 $times$ 1013 n.cm-2.s-1), the 

 specific activity of the microspheres (G75:Sm25, G50:Sm50 and 

 G25:Sm75) was 0.28, 0.54 and 0.58 GBq.g-1, respectively. 

 Therefore, the samarium microspheres produced in this study 

 provide great potential for improving internal radiotherapy 

 treatment for liver cancer by avoiding complex procedures and 

 using less microspheres with shorter irradiation time.},

keywords = {flame spheroidisation, Internal radiotherapy, Microspheres, Samarium-doped phosphate glass},

pubstate = {published},

tppubtype = {article}

}