Publications

@article{Rweyemamu2021-ik,

title = {The distribution of reproductive risk factors disclosed the 

 heterogeneity of receptor-defined breast cancer subtypes among 

 Tanzanian women},

author = {Linus P Rweyemamu and Gokce Akan and Ismael C Adolf and Erick P Magorosa and Innocent J Mosha and Nazima Dharsee and Lucy A Namkinga and Sylvester L Lyantagaye and Abdolrahman S Nateri and Fatmahan Atalar},

year  = {2021},

date = {2021-12-01},

journal = {BMC Womens. Health},

volume = {21},

number = {1},

pages = {423},

publisher = {Springer Science and Business Media LLC},

abstract = {BACKGROUND: Recent epidemiological studies suggest that 

 reproductive factors are associated with breast cancer (BC) 

 molecular subtypes. However, these associations have not been 

 thoroughly studied in the African populations. The present study 

 aimed to investigate the prevalence of BC molecular subtypes and 

 assess their association with reproductive factors in Tanzanian 

 BC patients. METHODS: This hospital-based case-only 

 cross-sectional study consisted of 263 histologically confirmed 

 BC patients in Tanzania. Clinico-pathological data, 

 socio-demographic characteristics, anthropometric measurements, 

 and reproductive risk factors were examined using the Chi-square 

 test and one-way ANOVA. The association among reproductive 

 factors and BC molecular subtypes was analyzed using multinomial 

 logistic regression. The heterogeneity of the associations was 

 assessed using the Wald test. RESULTS: We found evident subtype 

 heterogeneity for reproductive factors. We observed that 

 post-menopausal status was more prevalent in luminal-A subtype, 

 while compared to luminal-A subtype, luminal-B and HER-2 

 enriched subtypes were less likely to be found in post-menopausal women (OR: 0.21, 95%CI 0.10-0.4},

keywords = {Breast cancer, Heterogeneity, Molecular subtype, Reproductive   risk factors, Tanzania},

pubstate = {published},

tppubtype = {article}

}