Publications

@article{McCrorie2020-sx,

title = {Etoposide and olaparib polymer-coated nanoparticles within a 

 bioadhesive sprayable hydrogel for post-surgical localised 

 delivery to brain tumours},

author = {Phoebe McCrorie and Jatin Mistry and Vincenzo Taresco and Tatiana Lovato and Michael Fay and Ian Ward and Alison A Ritchie and Philip A Clarke and Stuart J Smith and Maria Marlow and Ruman Rahman},

year  = {2020},

date = {2020-12-01},

journal = {Eur. J. Pharm. Biopharm.},

volume = {157},

pages = {108\textendash120},

publisher = {Elsevier BV},

abstract = {Glioblastoma is a malignant brain tumour with a median survival 

 of 14.6 months from diagnosis. Despite maximal surgical 

 resection and concurrent chemoradiotherapy, reoccurrence is 

 inevitable. To try combating the disease at a stage of low 

 residual tumour burden immediately post-surgery, we propose a 

 localised drug delivery system comprising of a spray device, 

 bioadhesive hydrogel (pectin) and drug nanocrystals coated with 

 polylactic acid-polyethylene glycol (NCPPs), to be administered 

 directly into brain parenchyma adjacent to the surgical cavity. 

 We have repurposed pectin for use within the brain, showing in 

 vitro and in vivo biocompatibility, bio-adhesion to mammalian 

 brain and gelling at physiological brain calcium concentrations. 

 Etoposide and olaparib NCPPs with high drug loading have shown 

 in vitro stability and drug release over 120 h. Pluronic F127 

 stabilised NCPPs to ensure successful spraying, as determined by 

 dynamic light scattering and transmission electron microscopy. 

 Successful delivery of Cy5-labelled NCPPs was demonstrated in a 

 large ex vivo mammalian brain, with NCPP present in the tissue 

 surrounding the resection cavity. Our data collectively 

 demonstrates the pre-clinical development of a novel localised 

 delivery device based on a sprayable hydrogel containing 

 therapeutic NCPPs, amenable for translation to intracranial 

 surgical resection models for the treatment of malignant brain 

 tumours.},

keywords = {brain tumour, Etoposide, hydrogel, nanoparticles, Olaparib, Pectin, Spray},

pubstate = {published},

tppubtype = {article}

}