Publications

@article{Rogers2025-vw,

title = {Macrocyclic transition-metal parashift complexes for MRI at  clinical and pre-clinical magnetic fields},

author = {Nicola J Rogers and Chowan Ashok Kumar and Carlson Alexander and Daniel Bowdery and Galina Pavlovskaya and Peter Harvey},

doi = {10.1039/d5dt01149c},

year  = {2025},

date = {2025-07-01},

urldate = {2025-07-01},

journal = {Dalton Trans.},

volume = {54},

number = {28},

pages = {11036\textendash11046},

publisher = {Royal Society of Chemistry (RSC)},

abstract = {A series of macrocyclic transition-metal complexes, including 

 Fe(II), Co(II), Ni(II), and Cu(II) complexes, have been 

 evaluated for parashift MRI imaging applications, by assessing 

 their paramagnetic NMR properties, including proton chemical 

 shifts, nuclear relaxation rates, and any exchange dynamics in 

 solution, at magnetic fields strengths relevant to clinical and 

 pre-clinical imaging. Among the complexes studied, Fe(II) and 

 Co(II) systems demonstrated significant paramagnetic shifts with 

 desirable relaxation properties, making them potential 

 candidates for lanthanide-free parashift molecular probes for 

 MRI. Field-dependent nuclear relaxation rate analyses provided 

 insights into electronic relaxation times, confirming the 

 suitability of certain complexes for parashift imaging at lower 

 magnetic fields. Phantom imaging experiments at 9.4 T further 

 validated the feasibility of molecular imaging using a 

 cyclen-based macrocyclic Fe(II) complex, making a significant 

 advance toward developing transition metal-based MRI probes 

 using biogenic metal ions, and offer promise for future 

 responsive imaging due to the direct signal detection.},

keywords = {MRI},

pubstate = {published},

tppubtype = {article}

}

@article{Brewster2020-ly,

title = {Metallotexaphyrins as MRI-active catalytic antioxidants for 

 neurodegenerative disease: A study on Alzheimer's disease},

author = {James T 2nd Brewster and Gregory D Thiabaud and Peter Harvey and Hadiqa Zafar and James F Reuther and Simone Dell'Acqua and Rachel M Johnson and Harrison D Root and Pedro Metola and Alan Jasanoff and Luigi Casella and Jonathan L Sessler},

year  = {2020},

date = {2020-03-01},

journal = {Chem},

volume = {6},

number = {3},

pages = {703\textendash724},

publisher = {Elsevier BV},

abstract = {The complex etiology of neurodegeneration continues to stifle 

 efforts to develop effective therapeutics. New agents 

 elucidating key pathways causing neurodegeneration might serve 

 to increase our understanding and potentially lead to improved 

 treatments. Here, we demonstrate that a water-soluble 

 manganese(II) texaphyrin (MMn) is a suitable magnetic resonance 

 imaging (MRI) contrast agent for detecting larger amyloid beta 

 constructs. The imaging potential of MMn was inferred on the 

 basis of in vitro studies and in vivo detection in Alzheimer's 

 disease C. elegans models via MRI and ICP-MS. In vitro 

 antioxidant- and cellular-based assays provide support for the 

 notion that this porphyrin analog shows promise as a therapeutic 

 agent able to mitigate the oxidative and nitrative toxic effects 

 considered causal in neurodegeneration. The present report marks 

 the first elaboration of an MRI-active metalloantioxidant that 

 confers diagnostic and therapeutic benefit in Alzheimer's 

 disease models without conjugation of a radioisotope, targeting 

 moiety, or therapeutic payload.},

keywords = {Alzheimer\'s disease, amyloid   aggregation, amyloid beta, amyloid beta modifications by ROS and   RNS, C. elegans AD models, expanded porphyrin, metalloantioxidant, MRI, neurodegeneration, texaphyrin},

pubstate = {published},

tppubtype = {article}

}