Publications

@article{Yan2020-vl,

title = {Role of drugs used for chronic disease management on 

 susceptibility and severity of COVID-19: A large case-control 

 study},

author = {Huadong Yan and Ana M Valdes and Amrita Vijay and Shanbo Wang and Lili Liang and Shiqing Yang and Hongxia Wang and Xiaoyan Tan and Jingyuan Du and Susu Jin and Kecheng Huang and Fanrong Jiang and Shun Zhang and Nanhong Zheng and Yaoren Hu and Ting Cai and Guruprasad P Aithal},

year  = {2020},

date = {2020-12-01},

journal = {Clin. Pharmacol. Ther.},

volume = {108},

number = {6},

pages = {1185\textendash1194},

publisher = {Wiley},

abstract = {This study aimed to investigate whether specific medications 

 used in the treatment chronic diseases affected either the 

 development and/ or severity of coronavirus disease 2019 

 (COVID-19) in a cohort of 610 COVID-19 cases and 48,667 

 population-based controls from Zhejiang, China. Using a cohort 

 of 578 COVID-19 cases and 48,667 population-based controls from 

 Zhejiang, China, we tested the role of usage of cardiovascular, 

 antidiabetic, and other medications on risk and severity of 

 COVID-19. Analyses were adjusted for age, sex, and body mass 

 index and for presence of relevant comorbidities. Individuals 

 with hypertension taking calcium channel blockers had significantly increased risk (odds ratio (OR) = 1.73, 95% 

 confidence interval (CI) 1.2-2.3) of manifesting symptoms of 

 COVID-19, whereas those taking angiotensin receptor blockers and diuretics had significantly lower disease risk (OR = 0.22, 95% CI 0.15-0.30 and OR = 0.30, 95% CI 0.19-0.58, respectively). 

 Among those with type 2 diabetes, dipeptidyl peptidase-4 inhibitors (OR = 6.02, 95% CI 2.3-15.5) and insulin (OR = 2.71, 

 95% CI 1.6-5.5) were more and glucosidase inhibitors were less prevalent (OR = 0.11, 95% CI 0.1-0.3) among with patients with 

 COVID-19. Drugs used in the treatment of hypertension and 

 diabetes influence the risk of development of COVID-19, but, not 

 its severity.},

keywords = {#Joint first authors, Antidiabetic medications, Antihypertensive medications, Calcium channel   blockers, Corticosteroids, COVID-19, Risk, Severity},

pubstate = {published},

tppubtype = {article}

}