Publications

@article{Nicoletti2021-sw,

title = {Genetic risk factors in drug-induced liver injury due to 

 isoniazid-containing antituberculosis drug regimens},

author = {Paola Nicoletti and Harshad Devarbhavi and Ashish Goel and Radha Venkatesan and Chundamannil E Eapen and Jane I Grove and Samreen Zafer and Einar Bjornsson and M Isabel Lucena and Raul J Andrade and Munir Pirmohamed and Mia Wadelius and Dominique Larrey and Anke-Hilse Maitland-van der Zee and Luisa Ibanez and Paul B Watkins and Ann K Daly and Guruprasad P Aithal},

year  = {2021},

date = {2021-04-01},

journal = {Clin. Pharmacol. Ther.},

volume = {109},

number = {4},

pages = {1125\textendash1135},

publisher = {Wiley},

abstract = {Drug-induced liver injury (DILI) is a complication of treatment 

 with antituberculosis (TB) drugs, especially in isoniazid 

 (INH)-containing regimens. To investigate genetic risk factors, 

 we performed a genomewide association study (GWAS) involving 

 anti-TB DILI cases (55 Indian and 70 European) and controls 

 (1,199 Indian and 10,397 European). Most cases were treated with 

 a standard anti-TB drug regimen; all received INH. We imputed 

 single nucleotide polymorphism and HLA genotypes and performed 

 trans-ethnic meta-analysis on GWAS and candidate gene genotypes. 

 GWAS found one significant association (rs117491755) in 

 Europeans only. For HLA, HLA-B*52:01 was significant 

 (meta-analysis odds ratio (OR) 2.67, 95% confidence interval (CI) 1.63-4.3},

keywords = {adverse drug reactions, Drug-induced liver injury, genetic polymorphisms, HLA genes, isoniazid, N-acetyltransferase 2},

pubstate = {published},

tppubtype = {article}

}