Publications

@article{Rahman2023-fy,

title = {Childhood brain tumors: A review of strategies to translate 

 CNS drug delivery to clinical trials},

author = {Ruman Rahman and Miroslaw Janowski and Clare L Killick-Cole and William G B Singleton and Emma Campbell and Piotr Walczak and Soumen Khatua and Lukas Faltings and Marc Symons and Julia R Schneider and Kevin Kwan and John A Boockvar and Steven S Gill and J Miguel Oliveira and Kevin Beccaria and Alexandre Carpentier and Michael Canney and Monica Pearl and Gareth J Veal and Lisethe Meijer and David A Walker},

year  = {2023},

date = {2023-01-01},

journal = {Cancers (Basel)},

volume = {15},

number = {3},

pages = {857},

publisher = {MDPI AG},

abstract = {Brain and spinal tumors affect 1 in 1000 people by 25 years of 

 age, and have diverse histological, biological, anatomical and 

 dissemination characteristics. A mortality of 30-40% means the 

 majority are cured, although two-thirds have life-long 

 disability, linked to accumulated brain injury that is acquired 

 prior to diagnosis, and after surgery or chemo-radiotherapy. 

 Only four drugs have been licensed globally for brain tumors in 

 40 years and only one for children. Most new cancer drugs in 

 clinical trials do not cross the blood-brain barrier (BBB). 

 Techniques to enhance brain tumor drug delivery are explored in 

 this review, and cover those that augment penetration of the 

 BBB, and those that bypass the BBB. Developing appropriate 

 delivery techniques could improve patient outcomes by ensuring 

 efficacious drug exposure to tumors (including those that are 

 drug-resistant), reducing systemic toxicities and targeting 

 leptomeningeal metastases. Together, this drug delivery strategy 

 seeks to enhance the efficacy of new drugs and enable 

 re-evaluation of existing drugs that might have previously 

 failed because of inadequate delivery. A literature review of 

 repurposed drugs is reported, and a range of preclinical brain 

 tumor models available for translational development are 

 explored.},

keywords = {blood-brain barrier, brain tumor model, childhood brain tumors, companion animal, Drug delivery, drug repurposing, preclinical, xenograft},

pubstate = {published},

tppubtype = {article}

}