Publications

@article{Islam2021-qd,

title = {Effect of varying the Mg with Ca content in highly porous 

 phosphate-based glass microspheres},

author = {Md Towhidul Islam and Laura Macri-Pellizzeri and Kazi M Zakir Hossain and Virginie Sottile and Ifty Ahmed},

year  = {2021},

date = {2021-01-01},

journal = {Mater. Sci. Eng. C Mater. Biol. Appl.},

volume = {120},

number = {111668},

pages = {111668},

publisher = {Elsevier BV},

abstract = {This paper reports on the role of phosphate-based glass (PBG) 

 microspheres and their physicochemical properties including in 

 vitro biological response to human mesenchymal stem cells 

 (hMSCs). Solid and porous microspheres were prepared via a flame 

 spheroidisation process. The Mg content in the PBG formulations 

 explored was reduced from 24 to 2 mol% with a subsequent 

 increase in Ca content. A small quantity of TiO2 (1 mol%) was 

 added to the lower Mg-content glass (2 mol%) to avoid 

 crystallisation. Morphological and physical characterisation of 

 porous microspheres revealed interconnected porosity (up to 76 

 $±$ 5 %), average external pore sizes of 55 $±$ 5 μm 

 with surface areas ranging from 0.38 to 0.43 m2 g-1. Degradation 

 and ion release studies conducted compared the solid 

 (non-porous) and porous microspheres and revealed 1.5 to 2.5 

 times higher degradation rate for porous microspheres. Also, in 

 vitro bioactivity studies using simulated body fluid (SBF) 

 revealed Ca/P ratios for porous microspheres of all three glass 

 formulations were between 0.75 and 0.92 which were within the 

 range suggested for precipitated amorphous calcium phosphate. 

 Direct cell seeding and indirect cell culture studies (via 

 incubation with microsphere degradation products) revealed hMSCs 

 were able to grow and undergo osteogenic differentiation in 

 vitro, confirming cytocompatibility of the formulations tested. 

 However, the higher Mg content (24 mol%) porous microsphere 

 showed the most potent osteogenic response and is therefore 

 considered as a promising candidate for bone repair 

 applications.},

keywords = {bioactivity, cytocompatibility, Degradation, Ion release, osteogenic differentiation, porous microspheres, Thermal   properties},

pubstate = {published},

tppubtype = {article}

}