Publications

@article{McCrorie2020-ag,

title = {Biomedical engineering approaches to enhance therapeutic 

 delivery for malignant glioma},

author = {Phoebe McCrorie and Catherine E Vasey and Stuart J Smith and Maria Marlow and Cameron Alexander and Ruman Rahman},

year  = {2020},

date = {2020-12-01},

journal = {J. Control. Release},

volume = {328},

pages = {917\textendash931},

publisher = {Elsevier BV},

abstract = {We review the challenges of next-generation therapeutics for 

 both systemic and localised delivery to brain tumours and 

 discuss how recent engineering advances may be used to enhance 

 brain penetration of systemic delivery therapies. The unmet 

 clinical need which drug delivery seeks to address is discussed 

 with reference to the therapy obstacles that the intra-tumour 

 heterogeneity of glioma present. The unmet chemistry and 

 biomedical engineering challenge to develop controlled release 

 therapeutics is appraised, with commentary on current 

 success/failures in systemic carrier-mediated delivery, 

 including receptor-targeted, cell-based, blood-brain-barrier 

 disrupting and MRI-guided focused ultrasound. Localised 

 therapeutic delivery is a relatively under-studied research 

 avenue and is discussed with reference to existing technologies 

 in preclinical development. These include convection-enhanced 

 delivery, alternative catheter delivery, and neuro-surgically 

 applied delivery systems such as polymeric hydrogels and 

 interstitial spray. A myriad of nano-scale therapeutic delivery 

 systems is emerging as potential future medicines for malignant 

 brain tumours. Such biomedically-engineered systems will 

 increasingly feature in next-generation neuro-oncological 

 clinical trials to deliver repurposed and experimental 

 therapeutics, aimed at achieving therapeutic drug concentrations 

 in the brain, with associated mortality and morbidity benefits 

 for patients.},

keywords = {blood-brain-barrier, brain tumour, Drug delivery, nanoparticles, Polymers, Receptor-targeting},

pubstate = {published},

tppubtype = {article}

}