Publications

@article{Atallah2021-yd,

title = {Biomarkers of idiosyncratic drug-induced liver injury (DILI) - 

 a systematic review},

author = {Edmond Atallah and Cristiana Freixo and Ismael Alvarez-Alvarez and F J Cubero and Alexander L Gerbes and Gerd A Kullak-Ublick and Guruprasad P Aithal},

year  = {2021},

date = {2021-11-01},

journal = {Expert Opin. Drug Metab. Toxicol.},

volume = {17},

number = {11},

pages = {1327\textendash1343},

publisher = {Informa UK Limited},

abstract = {INTRODUCTION: Idiosyncratic drug-induced liver injury (DILI) is 

 an unpredictable event, and there are no specific biomarkers 

 that can distinguish DILI from alternative explanations or 

 predict its clinical outcomes. AREAS COVERED: This systematic 

 review summarizes the available evidence for all biomarkers 

 proposed to have a role in the diagnosis or prognosis of DILI. 

 Following a comprehensive search, we included all types of 

 studies in humans. We included DILI cases based on any threshold 

 criteria but excluded intrinsic DILI, commonly caused by 

 paracetamol overdose. We classified studies into diagnostic and 

 prognostic categories and assessed their methodological quality. 

 After reviewing the literature, 14 studies were eligible. EXPERT 

 OPINION: Diagnostic studies were heterogeneous with regard to 

 the study population and outcomes measured. Prognostic models 

 were developed by integrating novel biomarkers, risk scores, and 

 traditional biomarkers, which increased their prognostic ability 

 to predict death or transplantation by 6 months. This systematic 

 review highlights the case of need for non-genetic biomarkers 

 that distinguish DILI from acute liver injury related to 

 alternative etiology. Biomarkers with the potential to identify 

 serious adverse outcomes from acute DILI should be validated in 

 independent prospective cohorts with a substantial number of 

 cases.},

keywords = {biomarkers, DILI, Drug-induced liver injury, hepatotoxicity, systematic review},

pubstate = {published},

tppubtype = {article}

}