Publications

@article{Adolf2022-ur,

title = {HLA-G and single nucleotide polymorphism (SNP) associations 

 with cancer in African populations: Implications in personal 

 medicine},

author = {Ismael Chatita Adolf and Amany Almars and Nazima Dharsee and Teddy Mselle and Gokce Akan and Irene Jeremiah Nguma and Abdolrahman S Nateri and Fatmahan Atalar},

year  = {2022},

date = {2022-09-01},

journal = {Genes Dis.},

volume = {9},

number = {5},

pages = {1220\textendash1233},

publisher = {Elsevier BV},

abstract = {The immune system plays an important role in protecting the body 

 against malignancy. During cancer immunoediting, the immune 

 system can recognize and keep checking the tumor cells by 

 down-expression of some self-molecules or by increasing 

 expression of some novel molecules. However, the 

 microenvironment created in the course of cancer development 

 hampers the immune ability to recognize and destroy the 

 transforming cells. Human Leukocyte Antigen G (HLA-G) is 

 emerging as immune checkpoint molecule produced more by cancer 

 cells to weaken the immune response against them. HLA-G is a 

 non-classical HLA class I molecule which is normally expressed 

 in immune privileged tissues as a soluble or membrane-bound 

 protein. HLA-G locus is highly polymorphic in the non-coding 3' 

 untranslated region (UTR) and in the 5' upstream regulatory 

 region (5' URR). HLA-G expression is controlled by polymorphisms 

 located in these regions, and several association studies 

 between these polymorphic sites and disease predisposition, 

 response to therapy, and/or HLA-G protein expression have been 

 reported. Various polymorphisms are demonstrated to modulate its 

 expression and this is increasingly finding more significance in 

 cancer biology. This review focuses on the relevance of the 

 HLA-G gene and its polymorphisms in cancer development. We 

 highlight population genetics of HLA-G as evidence to espouse 

 the need and importance of exploring potential utility of HLA-G 

 in cancer diagnosis, prognosis and immunotherapy in the 

 currently understudied African population.},

keywords = {African population, Cancer, HLA-G, Immune system checkpoints, MHC, Single nucleotide polymorphism},

pubstate = {published},

tppubtype = {article}

}