Publications

@article{Robinson2021-la,

title = {The spectrum of Helicobacter-mediated diseases},

author = {Karen Robinson and John C Atherton},

year  = {2021},

date = {2021-01-01},

journal = {Annu. Rev. Pathol.},

volume = {16},

number = {1},

pages = {123\textendash144},

publisher = {Annual Reviews},

abstract = {Helicobacter pylori is the leading cause of peptic ulcer 

 disease. The infection has been implicated in more than 75% of 

 duodenal ulcer cases and 17% of gastric ulcer cases. H. pylori 

 has been classified as a human carcinogen, since it is the main 

 cause of distal gastric adenocarcinoma and B cell 

 mucosa-associated lymphoid tissue lymphoma. Evidence also links 

 H. pylori with extragastric conditions including iron deficiency 

 anemia, idiopathic thrombocytopenic purpura, and vitamin B12 

 deficiency. Studies indicate that H. pylori may be protective 

 against other conditions of the gastrointestinal tract (e.g., 

 reflux esophagitis and related pathologies) and elsewhere in the 

 body (e.g., asthma). The infection is asymptomatic in the vast 

 majority of cases; more serious outcomes occur in only 10-15% 

 of infected individuals. Despite extensive research over the 

 past 3 decades, there is no effective vaccine, and the 

 circumstances leading to disease development remain unclear. In 

 addition, there is now a growing prevalence of antimicrobial 

 resistance in H. pylori. This review discusses these important 

 issues.},

keywords = {antimicrobial resistance, duodenal ulcer, gastric adenocarcinoma, gastric ulcer, gastritis, Helicobacter pylori, MALT lymphoma, reflux esophagitis},

pubstate = {published},

tppubtype = {article}

}