Publications

@article{Hall2021-eq,

title = {Complex relationship between cardiac fibroblasts and 

 cardiomyocytes in health and disease},

author = {Caitlin Hall and Katja Gehmlich and Chris Denning and Davor Pavlovic},

year  = {2021},

date = {2021-02-01},

journal = {J. Am. Heart Assoc.},

volume = {10},

number = {5},

pages = {e019338},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {Cardiac fibroblasts are the primary cell type responsible for 

 deposition of extracellular matrix in the heart, providing 

 support to the contracting myocardium and contributing to a 

 myriad of physiological signaling processes. Despite the 

 importance of fibrosis in processes of wound healing, excessive 

 fibroblast proliferation and activation can lead to pathological 

 remodeling, driving heart failure and the onset of arrhythmias. 

 Our understanding of the mechanisms driving the cardiac 

 fibroblast activation and proliferation is expanding, and 

 evidence for their direct and indirect effects on cardiac 

 myocyte function is accumulating. In this review, we focus on 

 the importance of the fibroblast-to-myofibroblast transition and 

 the cross talk of cardiac fibroblasts with cardiac myocytes. We 

 also consider the current use of models used to explore these 

 questions.},

keywords = {arrhythmias, cardiac fibroblasts, cardiomyocytes, fibrosis, heart failure, myofibroblast},

pubstate = {published},

tppubtype = {article}

}