Publications

@article{Bastiancich2021-ob,

title = {Rationally designed drug delivery systems for the local 

 treatment of resected glioblastoma},

author = {Chiara Bastiancich and Alessio Malfanti and V\'{e}ronique Pr\'{e}at and Ruman Rahman},

year  = {2021},

date = {2021-10-01},

journal = {Adv. Drug Deliv. Rev.},

volume = {177},

number = {113951},

pages = {113951},

publisher = {Elsevier BV},

abstract = {Glioblastoma (GBM) is a particularly aggressive brain cancer 

 associated with high recurrence and poor prognosis. The standard 

 of care, surgical resection followed by concomitant radio- and 

 chemotherapy, leads to low survival rates. The local delivery of 

 active agents within the tumor resection cavity has emerged as 

 an attractive means to initiate oncological treatment 

 immediately post-surgery. This complementary approach bypasses 

 the blood-brain barrier, increases the local concentration at 

 the tumor site while reducing or avoiding systemic side effects. 

 This review will provide a global overview on the local 

 treatment for GBM with an emphasis on the lessons learned from 

 past clinical trials. The main parameters to be considered to 

 rationally design fit-of-purpose biomaterials and develop drug 

 delivery systems for local administration in the GBM resection 

 cavity to prevent the tumor recurrence will be described. The 

 intracavitary local treatment of GBM should i) use materials 

 that facilitate translation to the clinic; ii) be characterized 

 by easy GMP effective scaling up and easy-handling application 

 by the neurosurgeons; iii) be adaptable to fill the 

 tumor-resected niche, mold to the resection cavity or adhere to 

 the exposed brain parenchyma; iv) be biocompatible and possess 

 mechanical properties compatible with the brain; v) deliver a 

 therapeutic dose of rationally-designed or repurposed drug 

 compound(s) into the GBM infiltrative margin. Proof of concept 

 with high translational potential will be provided. Finally, 

 future perspectives to facilitate the clinical translation of 

 the local perisurgical treatment of GBM will be discussed.},

keywords = {Brain cancer, Controlled drug delivery, Glioblastoma, Hydrogels, Local drug delivery, Nanomedicine},

pubstate = {published},

tppubtype = {article}

}